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How sickle cell protects against malaria

How sickle cell protects against malaria

Sickle cell disease (SCD) affects millions of people around the globe and is the 4th leading cause of deaths in children in many developing countries. It is a hereditary disease. It causes a number of health problems, such as attacks of pain, anaemia, swelling in the hands and feet, bacterial infections and stroke. Sickle-cell contributes to a low life expectancy in the developed world of 40 to 60 years.
Scientists have proven that sickle cell patients don't suffer malaria. This is because

1)humans/animals with the sickle-cell trait have to break down and detoxify misshapen red blood cells their entire lives. Therefore, infected sickled red blood cell are actually a hostile environment for the plasmodium parasite that causes malaria.

2) The sickle cells have membranes, stretched by their unusual shape, that become porous and leak nutrients that the parasites need to survive and the faulty cells eventually get eliminated quite fast by the organisms, destroying the parasite along the way.

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........is the 4th leading cause of deaths in children in many developing countries.