Tonto Dikeh was born into a family of seven and is the third of five children. Her family is from Obio-Akpor, a LGA in Rivers State, and is of Ikwerre descent. At age 3, she lost her mother and was raised by her step-mother, who has two children. Dikeh studied petrochemical engineering at the Rivers State University of Science and Technology. Her traditional marriage to Oladunni Churchill was held in August 2015. In February 2016, Dikeh gave birth to her son Andre Omodayo Churchill, whom she nicknamed Baby X. However since then the couple has gone there different ways.
She was featured in a movie titled Dirty Secret, which generated controversy among Nigerians due to its inclusion of adult scenes. While some people criticized her role for being nontraditional and un-African, others stated that Dikeh was merely being professional.
Following a successful acting career, Dikeh decided to pursue a music career. Prior to that, she was featured in a music video for Amaco Investments, alongside Patience Ozokwor. She made her music debut by releasing the singles "Hi" and "Itz Ova", the latter of which features Snypa. On 13 June 2014, Nigerian singer D'banj signed her to his record label, DB Records. Dikeh announced her departure from DB records in March 2015.
On May 23, 2019, Tonto Dikeh signed a USD $5000 deal with Zikel Cosmetics setting on the map for being the first Nigerian celebrity to be paid such amount for being an ambassador of a makeup brand in Africa.